![]() ![]() WARNING Be aware that lithium affects intracellular and extracellular potassium ion shift, which can cause ECG changes, such as flattened or inverted T waves lithium also can increase the risk of cardiac arrest. Even a slightly high blood level is dangerous, and some patients exhibit signs of toxicity at normal levels.Įxpect prescriber to decrease dosage after acute manic episode is controlled. In uncomplicated cases, plan to monitor lithium level every 2 to 3 months.īe aware that lithium has a narrow therapeutic range. Note that 5 ml of lithium citrate equals 8 mEq of lithium ion or 300 mg of lithium carbonate.Įxpect to monitor blood lithium level two or three times weekly during first month, and then weekly to monthly during maintenance therapy and when initiating or discontinuing NSAID therapy. Dilute syrup with juice or other flavored drink before giving. High-sodium foods: Increased excretion and possibly decreased therapeutic effects of lithiumĪdminister lithium after meals to slow absorption from GI tract and reduce adverse reactions. Tricyclic antidepressants: Possibly severe mood swings from mania to depression Thyroid hormones: Possibly hypothyroidism Selective serotonin reuptake inhibitors: Increased risk of adverse effects, such as diarrhea, confusion, dizziness, agitation, and tremor Norepinephrine: Possibly decreased therapeutic effects of norepinephrine and severe respiratory depression Neuromuscular blockers: Risk of prolonged paralysis or weakness Haloperidol and other antipyschotics: Increased risk of irreversible neurotoxicity and brain damage ACE inhibitors, NSAIDs, piroxicam: Possibly increased blood lithium level and increased risk of toxicityĪcetazolamide, sodium bicarbonate, urea, xanthines: Decreased blood lithium levelĬalcium channel blockers, molindone: Increased risk of neurotoxicity from lithiumĬalcium iodide, iodinated glycerol, potassium iodide: Possibly increased hypothyroid effects of both drugsĬarbamazepine: Possibly increased therapeutic effects of carbamazepine and neurotoxic effect of lithiumĬhlorpromazine, other phenothiazines: Possibly impaired GI absorption and decreased blood levels of these drugs possibly masking of early signs of lithium toxicityĭesmopressin, lypressin, vasopressin: Possibly impaired antidiuretic effects of these drugsĭiuretics (loop and osmotic): Increased lithium reabsorption by kidneys, possibly leading to lithium toxicityįluoxetine, methyldopa, metronidazole: Increased risk of lithium toxicity from reduced renal clearance of lithiun
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |